Photoswitchable Metallo-Cages & Supramolecular Assemblies

This project designs and synthesises photoswitchable metallo-cages and supramolecular assemblies for the light-controlled capture and release of target molecules. Built via self-assembly, these architectures rely on dynamic, reversible non-covalent interactions to selectively bind guest substrates within their internal cavities.

Using specific wavelengths of light as a clean, non-invasive trigger, we drive structural changes that alter cavity shape and binding affinity—effectively switching molecular encapsulation “on” and “off” on demand.

This dynamic, stimuli-responsive control unlocks significant potential for real-world applications where precise timing and location matter. Key targets include on-demand drug delivery to reduce off-target side effects, controlled pesticide release for sustainable agriculture, and selective pollutant capture for environmental remediation.

Key Research Objectives

• Self-Assembly of Photo-Responsive Hosts: Synthesising ligand and building-block libraries embedded with molecular photoswitches to construct discrete metallo-cages and dynamic supramolecular assemblies.
• Light-Modulated Cavity Geometry: Using UV-Vis, NMR spectroscopy, X-ray crystallography and computational analysis to map how photoisomerisation reshapes internal binding pockets and switches host–guest affinity.
• Targeted Delivery & Remediation: Applying light-triggered uptake and release to controlled drug delivery, smart agrochemical release, and selective environmental capture.

Student Opportunities

• PhD, Masters & Honours Projects Available: This project provides comprehensive training in organic ligand synthesis, coordination self-assembly, photochemistry, computational chemistry and host–guest binding studies.
• Get in Touch: Prospective Honours, Masters, or PhD candidates interested in this project are welcome to get in touch via email to discuss current opportunities.